Serotonin syndrome Thesis Example | Topics and Well Written Essays - 1500 words

Serotonin syndrome - Thesis Example The determining factor in disease management is therefore, early recognition of the symptoms, which themselves are the major diagnostic factors. The essay is an outline of the researches contributing to an understanding of the various aspects of the disease. Introduction: Serotonin syndrome is a combination of symptoms that occur as a result of overstimulation of specific serotonin receptors. It usually develops as a consequence of administration of more than one (rarely one) drug that is a serotonergic agent. Described as a possibility first in 1955 by Mitchell, in a tuberculosis patient administered iproniazid and meperidine simultaneously, the disease has been in existence since much longer. Initially studied as a behavioural disorder exclusively in animals (Grahame-Smith, 1971), the disease was much later associated with humans (Insel et al., 1982). The increase in incidences of the syndrome was reported as a consequence of prescribing selective serotonin reuptake inhibitors (SSRI) for treatment of depression, which lead to an interest in serotonin syndrome. The disease is characterized by restlessness, incessant twitching, excitement, agitation and tremor or shivering. The disease severity can vary from mild to intense, though seve re cases of disease are rarely reported and can be treated by withdrawal of causative agents as well as use of serotonin antagonists. In its most severe form the disease can even be life threatening. Serotonin: Chemically 5-hydroxytryptamin or 5HT, Serotonin is a neurotransmitter formed by hydroxylation and decarboxylation of amino acid tryptophan. It is involved in the control and expression of a plethora of feelings ranging from depression and psychosis, to hunger and slumber. It also plays important role in body temperature, sexual behaviour, pain and memory. Serotonin secreting neurons are known as serotonergic. However, serotonin function is determined

Organisational Change management Essay Example | Topics and Well Written Essays - 500 words

Organisational Change management - Essay Example changing into the new Strategic Direction are based on the fact that the Suffolk County Council requires radical changes that will reduce their costs. Currently, it has become too slow, complex, overelaborate, risk adverse, serves the regulator more than the customer, and too expensive considering the impeding financial crisis. This program will reshape the Council’ way of thinking and provide radical solutions to the financial problems affecting the council. It will also make the council leaner, smaller, cheaper, more creative, and more innovative by developing more commercial skills which will enable the council to understand its costs better so as to reduce them. The budget gap of the council is expected to rise to  £153 million by 2013. Attempts to reduce the staffing costs the budget gap by laying off promises no solution to the budget gap as it will save only  £55m out of the  £153m from the lost 400 jobs. Furthermore, the council has no capacity of running a big r edundancy programme for its staff. The program is focused on challenging spending and reducing costs so that the  £153m budget gap will not be realized. The program addresses the  £153m budget gap by reducing the demand for their services. This will entail addressing the root cause of social problems and solving them and also building social capital to strengthen communities to be able to solve their own problems. This proposal will include the description of the current situation; this section will address the current issues facing the Suffolk County Council and why changes should be implemented. Next will be the goals of the proposal; based on the assessment of the problems facing the Suffolk County Council, this section will provide the New Strategic Direction and the solution it offers to the council. This section will be followed by proposed Methodology; this section will address a step by step process of implementing the New Strategic Direction until its goals are realized. Time and cost